Stem cell therapy after a heart attack repairs the heart muscle
Researchers at the Mayo Clinic in the USA have discovered a new healing method using stem cell therapy after a heart attack. Activated stem cells restored the heart muscle to its state before asystole. This also provided a blueprint for how stem cells work.
Successful stem cell therapy after heart attack
The new study shows that human cells in the heart examine damaged proteins to reverse complex changes caused by a heart attack. This species mainly comes from adult stem cells and sources of the bone marrow.
The extent of the change caused by a heart attack is sometimes too great. However, the heart could also repair itself or prevent further damage. In particular, stem cell therapy after myocardial infarction reversed changes in whole or in part to two thirds of these diseases, so that 85% of all cellular categories affected by diseases responded positively to the treatment. That is shared by Andre Terzic, director of the Center for Regenerative Medicine. He is the lead author of the study.
So this is a new understanding of how stem cells restore heart health. In addition, it could provide the framework for broader stem cell therapy applications under various conditions.
The actual mode of action of stem cells in the repair of a diseased organ is so far only insufficiently known. This limits acceptance in clinical care. This study highlights the most comprehensive mechanisms for regeneration that form a plan for responsible and increasing action.
Heart disease is one of the most common causes of death. During a heart attack, the heart tissue dies and weakens the heart. The reaction of the diseased heart to the treatment of stem cells showed the development and growth of new blood vessels and new heart tissue.
Study results
The researchers compared the diseased hearts of laboratory mice that did not receive stem cell therapy after myocardial infarction to those who did. Using a scientific approach to map all proteins in the heart muscle, the researchers identified 4,000 proteins. Of those, more than 10% were affected by a heart attack.
The scientists expected that stem cell therapy would lead to an advantageous result. However, they are surprised at how far this method has brought the condition of the diseased heart back to a healthy state before the illness. Such stem cells are being tested in advanced clinical trials in cardiac patients. The current findings of this study will enrich the knowledge base for stem cell therapies and may have the potential to control future therapies.
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