Obesity treatment with newly discovered protein BAM15
Researchers recently discovered a protein called BAM15 that medicine can use as a potential obesity treatment. The study results show that obesity and the associated diseases can be influenced by it. It also provides the first evidence that BAM15 acts as an energy decoupler and could be an effective weight loss medication.
Possible obesity treatment in sight
Obesity affects millions of people worldwide and leads to health problems such as heart disease, diabetes and many types of cancer. The currently available obesity therapy rarely achieves a weight loss of more than 10% and cannot offer long-term weight control to patients. An alternative approach to reducing food intake is to reduce metabolic efficiency. Mitochondrial protonophore decouplers with small molecules reduce mitochondrial coupling efficiency. This leads to increased nutrient oxidation to produce a certain amount of adenosine triphosphate (ATP). The study showed that the mitochondrial decoupler 2,4-dinitrophenol (DNP) has some effects in weight loss in obese people. However, DNP has a narrow window between effective and toxic doses.
The BAM15 protein differs from existing weight loss medications, which work primarily by reducing the amount of food a person eats or the calories their body consumes. It also works by making mitochondria, the cell’s power plants, less efficient. The result is that the mitochondria burn more energy. This research represents a promising step in the discovery process. Scientists hope that BAM15 or related compounds will drive the clinical development of drugs in the not too distant future. This can make it a viable treatment option for patients with obesity. So they believe that BAM15 can be used not only to treat obesity, but also for a range of health conditions. These include diabetes and fatty liver disease as well as some forms of cancer.
research results
In the new study, Pennington Biomedical scientists in Los Angeles show for the first time that mice given BAM15 are resistant to weight gain. This is done by burning more calories than their untreated counterparts. Other benefits of BAM15 include reducing blood sugar and insulin levels regardless of weight loss. It also improves skeletal muscle sensitivity to the effects of insulin. Insulin resistance of the skeletal muscles is a major risk factor for the development of type 2 diabetes. The protein also reduces overall fat accumulation by preventing the fat in the liver, kidneys and blood. The accumulation of too much fat in these organs can damage them and lead to heart disease.
The researchers observed that BAM15 greatly increased mitochondrial respiration and sustained activity. Improved regulation of body weight has been observed along with a reduction in fat accumulation, an improvement in the release of glucose throughout the body, and energy consumption without changing body temperature. In contrast to conventional weight loss drugs, BAM15 did not reduce the amount of food consumed, but made the mitochondria less efficient. The scientists published the study in the journal EMBO Molecular Medicine.
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