Nobiletin in oranges and tangerines: active ingredient against obesity?
The nobiletin molecule in oranges could reverse obesity as the equivalent of just two and a half glasses of orange juice a day. This could reduce the risk of heart disease and diabetes as an additive in medication. This is an advantage western researchers attribute to the flavonoid. This extract is mainly used as an active ingredient in sweet oranges and tangerines.
Nobiletin effective in oranges
The study showed that mice that fed researchers a high-fat diet but also administered nobiletin were significantly leaner than other laboratory mice. The scientists fed a large amount of cholesterol to the mice, but they showed reduced insulin resistance and blood lipids.
“We have also shown that we can also intervene in oranges with nobiletin,” said Schulich professor Murray Huff, who has been studying the effects of nobiletin for more than a decade. “We have shown that in mice that already have all the negative symptoms of obesity, we can use nobiletin to reverse these symptoms, and even reduce the plaque build-up in the arteries known as atherosclerosis.”
However, Huff also says that he and his team still could not know exactly how Nobiletin works. The researchers hypothesized that the molecule is likely to act on the pathway that regulates fat handling in the body. This regulator, called AMP Kinase, turns on the machinery in the body that burns fats to generate energy. This process therefore blocks the production of fats. However, when the researchers examined the effects of nobiletin on mice that were genetically modified, they did not see the same effect.
Study results
“This result showed us that nobiletin does not act on AMP kinase and bypasses this main regulator of the use of fat in the body. What is left is the question of how Nobiletin does it? ”
He also says that while the mystery persists, this recent finding is still clinically important. It shows that nobiletin does not interfere with other drugs that work to burn fat. In his opinion, current therapeutic agents for diabetes like metformin also work in this way. The next step is primarily to transfer these studies to humans. We can thus determine whether nobiletin in oranges has the same positive effects on the metabolism.
“Obesity and the resulting metabolic syndromes are a huge burden on our health system. We have very few interventions that have been shown to work effectively,” said Huff. “We must continue to focus on the discovery of new therapeutics from the study.”
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